Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist

Mohammed Allam

doi:doi:10.11648/j.ajpn.20221004.14

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Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist

Mohammed Allam

Published in American Journal of Psychiatry and Neuroscience (Volume 10, Issue 4)

Received: 17 October 2022 Accepted: 2 November 2022 Published: 16 November 2022

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Abstract

Methodology of clinical trials is a major determinant to their level of evidenced based medicine. Prospective longitudinal trials such as randomized controlled trials (RCT) have significant position in the hierarchy of evidenced based practice. One of the shortcomings of the RCT could be in the inclusion and exclusion criteria unlike real life settings with clinical decisions made by a psychiatrist due to clinical necessity and not for a protocol necessity or earlier deadlines for data collection. Retrospective analysis gives time to see consistent response over time in real life settings not only six to eight weeks’ response to an antidepressant. Multicenter retrospective analyses by different research groups involving the same antidepressant have the shortcomings of including different cut off points, different inclusion and exclusion criteria or different statistical tools causing challenges in the extrapolation of data. Retrospective interpretation of notes or tools used by different colleagues could be challenging due to interrater reliability issues even with same tool used by different colleagues with different levels of training on/agreement on score allocations for particular patients’ responses. Interpreting what others meant by their notes is another challenge. Questionnaires filled by patients alone in waiting rooms to save time are liable to mistakes and misinterpretations. The aim of this paper is to propose a retrospective naturalistic study to be conducted by the same treating psychiatrist for patients treated with Vortioxetine as a mono/combination therapy for at least a year trying to reduce the interrater errors with the suggested aid in appendixes included.

Published in	American Journal of Psychiatry and Neuroscience (Volume 10, Issue 4)
DOI	10.11648/j.ajpn.20221004.14
Page(s)	182-187
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Vortioxetine, Retrospective Analysis, Naturalistic Retrospective Analysis, Antidepressant Therapy

References

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[3]	N. Institute for Clinical Excellence (NICE) (ed.) (2010) The Treatment and Management of Depression in Adults (updated edition), National Clinical Practice Guideline 90, London, The British Psychological Society and The Royal College of Psychiatrists.
[4]	Khan, Arif; Mar, Kaysee Fahla; Brown, Walter A. c. The conundrum of depression clinical trials: one size does not fit all. International Clinical Psychopharmacology: September 2018 - Volume 33 - Issue 5 - p 239-248.
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[11]	Dale E, et al., The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices. Brain Res. 2018 Jun 15; 1689: 1-11. doi: 10.1016/j.brainres.2017.12.025. Epub 2017 Dec 21. PMID: 29274875.
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Mohammed Allam. (2022). Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. American Journal of Psychiatry and Neuroscience, 10(4), 182-187. https://doi.org/10.11648/j.ajpn.20221004.14

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ACS Style

Mohammed Allam. Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. Am. J. Psychiatry Neurosci. 2022, 10(4), 182-187. doi: 10.11648/j.ajpn.20221004.14

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AMA Style

Mohammed Allam. Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. Am J Psychiatry Neurosci. 2022;10(4):182-187. doi: 10.11648/j.ajpn.20221004.14

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@article{10.11648/j.ajpn.20221004.14,
  author = {Mohammed Allam},
  title = {Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {4},
  pages = {182-187},
  doi = {10.11648/j.ajpn.20221004.14},
  url = {https://doi.org/10.11648/j.ajpn.20221004.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221004.14},
  abstract = {Methodology of clinical trials is a major determinant to their level of evidenced based medicine. Prospective longitudinal trials such as randomized controlled trials (RCT) have significant position in the hierarchy of evidenced based practice. One of the shortcomings of the RCT could be in the inclusion and exclusion criteria unlike real life settings with clinical decisions made by a psychiatrist due to clinical necessity and not for a protocol necessity or earlier deadlines for data collection. Retrospective analysis gives time to see consistent response over time in real life settings not only six to eight weeks’ response to an antidepressant. Multicenter retrospective analyses by different research groups involving the same antidepressant have the shortcomings of including different cut off points, different inclusion and exclusion criteria or different statistical tools causing challenges in the extrapolation of data. Retrospective interpretation of notes or tools used by different colleagues could be challenging due to interrater reliability issues even with same tool used by different colleagues with different levels of training on/agreement on score allocations for particular patients’ responses. Interpreting what others meant by their notes is another challenge. Questionnaires filled by patients alone in waiting rooms to save time are liable to mistakes and misinterpretations. The aim of this paper is to propose a retrospective naturalistic study to be conducted by the same treating psychiatrist for patients treated with Vortioxetine as a mono/combination therapy for at least a year trying to reduce the interrater errors with the suggested aid in appendixes included.},
 year = {2022}
}

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TY  - JOUR
T1  - Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist
AU  - Mohammed Allam
Y1  - 2022/11/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221004.14
DO  - 10.11648/j.ajpn.20221004.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 182
EP  - 187
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221004.14
AB  - Methodology of clinical trials is a major determinant to their level of evidenced based medicine. Prospective longitudinal trials such as randomized controlled trials (RCT) have significant position in the hierarchy of evidenced based practice. One of the shortcomings of the RCT could be in the inclusion and exclusion criteria unlike real life settings with clinical decisions made by a psychiatrist due to clinical necessity and not for a protocol necessity or earlier deadlines for data collection. Retrospective analysis gives time to see consistent response over time in real life settings not only six to eight weeks’ response to an antidepressant. Multicenter retrospective analyses by different research groups involving the same antidepressant have the shortcomings of including different cut off points, different inclusion and exclusion criteria or different statistical tools causing challenges in the extrapolation of data. Retrospective interpretation of notes or tools used by different colleagues could be challenging due to interrater reliability issues even with same tool used by different colleagues with different levels of training on/agreement on score allocations for particular patients’ responses. Interpreting what others meant by their notes is another challenge. Questionnaires filled by patients alone in waiting rooms to save time are liable to mistakes and misinterpretations. The aim of this paper is to propose a retrospective naturalistic study to be conducted by the same treating psychiatrist for patients treated with Vortioxetine as a mono/combination therapy for at least a year trying to reduce the interrater errors with the suggested aid in appendixes included.
VL  - 10
IS  - 4
ER  -

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Author Information

Mohammed Allam

Department of Adult Psychiatry, American Center for Psychiatry and Neurology (ACPN), Al Ain, United Arab Emirates (UAE)

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APA Style

Mohammed Allam. (2022). Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. American Journal of Psychiatry and Neuroscience, 10(4), 182-187. https://doi.org/10.11648/j.ajpn.20221004.14

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ACS Style

Mohammed Allam. Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. Am. J. Psychiatry Neurosci. 2022, 10(4), 182-187. doi: 10.11648/j.ajpn.20221004.14

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AMA Style

Mohammed Allam. Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist. Am J Psychiatry Neurosci. 2022;10(4):182-187. doi: 10.11648/j.ajpn.20221004.14

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@article{10.11648/j.ajpn.20221004.14,
  author = {Mohammed Allam},
  title = {Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {4},
  pages = {182-187},
  doi = {10.11648/j.ajpn.20221004.14},
  url = {https://doi.org/10.11648/j.ajpn.20221004.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221004.14},
  abstract = {Methodology of clinical trials is a major determinant to their level of evidenced based medicine. Prospective longitudinal trials such as randomized controlled trials (RCT) have significant position in the hierarchy of evidenced based practice. One of the shortcomings of the RCT could be in the inclusion and exclusion criteria unlike real life settings with clinical decisions made by a psychiatrist due to clinical necessity and not for a protocol necessity or earlier deadlines for data collection. Retrospective analysis gives time to see consistent response over time in real life settings not only six to eight weeks’ response to an antidepressant. Multicenter retrospective analyses by different research groups involving the same antidepressant have the shortcomings of including different cut off points, different inclusion and exclusion criteria or different statistical tools causing challenges in the extrapolation of data. Retrospective interpretation of notes or tools used by different colleagues could be challenging due to interrater reliability issues even with same tool used by different colleagues with different levels of training on/agreement on score allocations for particular patients’ responses. Interpreting what others meant by their notes is another challenge. Questionnaires filled by patients alone in waiting rooms to save time are liable to mistakes and misinterpretations. The aim of this paper is to propose a retrospective naturalistic study to be conducted by the same treating psychiatrist for patients treated with Vortioxetine as a mono/combination therapy for at least a year trying to reduce the interrater errors with the suggested aid in appendixes included.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Vortioxetine Retrospective Study in MDD: A Proposal for Outcome Analysis by the Treating Psychiatrist
AU  - Mohammed Allam
Y1  - 2022/11/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221004.14
DO  - 10.11648/j.ajpn.20221004.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 182
EP  - 187
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221004.14
AB  - Methodology of clinical trials is a major determinant to their level of evidenced based medicine. Prospective longitudinal trials such as randomized controlled trials (RCT) have significant position in the hierarchy of evidenced based practice. One of the shortcomings of the RCT could be in the inclusion and exclusion criteria unlike real life settings with clinical decisions made by a psychiatrist due to clinical necessity and not for a protocol necessity or earlier deadlines for data collection. Retrospective analysis gives time to see consistent response over time in real life settings not only six to eight weeks’ response to an antidepressant. Multicenter retrospective analyses by different research groups involving the same antidepressant have the shortcomings of including different cut off points, different inclusion and exclusion criteria or different statistical tools causing challenges in the extrapolation of data. Retrospective interpretation of notes or tools used by different colleagues could be challenging due to interrater reliability issues even with same tool used by different colleagues with different levels of training on/agreement on score allocations for particular patients’ responses. Interpreting what others meant by their notes is another challenge. Questionnaires filled by patients alone in waiting rooms to save time are liable to mistakes and misinterpretations. The aim of this paper is to propose a retrospective naturalistic study to be conducted by the same treating psychiatrist for patients treated with Vortioxetine as a mono/combination therapy for at least a year trying to reduce the interrater errors with the suggested aid in appendixes included.
VL  - 10
IS  - 4
ER  -

Copy | Download