Research Article
Isolated Intracranial Rosai-Dorfman Disease: A Diagnostic Challenge
Issue:
Volume 8, Issue 3, September 2024
Pages:
32-37
Received:
19 May 2024
Accepted:
8 October 2024
Published:
29 October 2024
DOI:
10.11648/j.cnn.20240803.11
Downloads:
Views:
Abstract: Rosai-Dorfman disease (RDD) is a benign condition characterized by abnormal proliferation of white blood cells called histiocytes and an uncommon biological process called emperipolesis, in which a living cell penetrates inside another living cell. Central nervous system involvement in RDD is extremely rare. We report one such rare case of 47-year- old man who presented with right sided focal seizure from 1 year. MRI Brain showed a dural based lesion. On the basis of clinical presentation and radiological findings initial diagnosis made was of en plaque meningioma. Gross total resection of lesion was performed. Initial histopathological diagnosis was of IgG4 related HPM. Post surgery there was significant improvement in patients clinical condition. Intensity of seizure episodes were reduced. However due to persistence of right sided focal seizures, tissue blocks were reviewed and diagnosis of intracranial Rosai-Dorfman disease was made. Upon which further hematologist opinion was taken and whole body PET CT was done which showed solitary uptake in brain. It was observed that characteristic feature of RDD emperipolesis is sometimes masked by storiform fibrosis and lymphocytic infiltration leading to misdiagnosis. Therefore close follow up is required, in case of persistence of symptoms tissue blocks should be reviewed and possibility of intracranial Rosai-Dorfman disease should be considered while dealing with dural based lesions.
Abstract: Rosai-Dorfman disease (RDD) is a benign condition characterized by abnormal proliferation of white blood cells called histiocytes and an uncommon biological process called emperipolesis, in which a living cell penetrates inside another living cell. Central nervous system involvement in RDD is extremely rare. We report one such rare case of 47-year-...
Show More
Research Article
Suppletion and Compensation in the Clinic of Ordinary Psychoses
Marco Maximo Balzarini*
Issue:
Volume 8, Issue 3, September 2024
Pages:
38-46
Received:
14 September 2024
Accepted:
4 October 2024
Published:
29 October 2024
DOI:
10.11648/j.cnn.20240803.12
Downloads:
Views:
Abstract: This work aims to differentiate two modalities of response of the subject to the confrontation with non-dialectizable jouissance: symptomatic substitution through the Borromeo node and conformist identification through the imaginary register. Such differentiation is based on one direction: the clinic of operation. The orientation of this clinic is based on this back and forth of difference and similarity between both responses of the subject to the real, which establishes a contradiction that must be sustained, a contradiction that underlies what is proposed in this work as the beginning of a new paradigm in psychopathology given by the field that opens with the signifier introduced by Jacques-Alain Miller, ordinary psychoses, and that continues with the idea of this functional paradox. The question that leads is how does a new paradigm arise in psychopathology of the categorical, but functional distinction between the modalities of possible response of an ordinary psychotic subject to the confrontation with the real of jouissance? The methodology to carry out this research will be the review of the bibliographic background, the subsequent ordering and the operation of the content analysis in the differential categories mentioned from a qualitative approach. It is concluded that psychosis, from this functional paradox, is not a disease, but the introduction of a new logic that could constitute a paradigm in the current psychiatric clinic.
Abstract: This work aims to differentiate two modalities of response of the subject to the confrontation with non-dialectizable jouissance: symptomatic substitution through the Borromeo node and conformist identification through the imaginary register. Such differentiation is based on one direction: the clinic of operation. The orientation of this clinic is ...
Show More
